The fighter crashed in highlands after it took off from a military air base in Dezful, 460 kilometers (280 miles) southwest of the capital, Tehran.
Morad Nasseri, governor of the nearby Abdanan region said two pilots were killed in the crash.
The Iranian regime’s air force has an assortment of U.S.-made military aircraft, including F-5 Phantoms, purchased before the 1979 Revolution. It has also Russian-made MiG and Sukhoi planes.